Boosting NAD+ Levels

The primary proposed benefit of NMN is its ability to effectively increase NAD+ levels in the body. As we age, our natural NAD+ levels decline, which is believed to contribute to many age-related health issues. By providing NMN, the body can synthesize more NAD+, potentially restoring levels closer to those seen in younger individuals.

Studies in both animals and a growing number of human trials have consistently shown that NMN supplementation can significantly increase NAD+ concentrations in various tissues and in the bloodstream.

Cellular Energy Metabolism

NAD+ is a critical component of cellular energy production, particularly in the mitochondria (often called the 'powerhouses' of the cell). By optimizing NAD+ levels, NMN may support more efficient energy conversion from food, potentially leading to increased vitality and reduced fatigue.

Animal studies have shown enhanced energy metabolism and physical activity with NMN supplementation. Early human research indicates potential for improved measures of aerobic capacity and reduced drowsiness, particularly in older adults.

DNA Repair and Genomic Stability

Our DNA is constantly subjected to damage. NAD+ is essential for the function of sirtuins, a class of proteins often referred to as 'longevity genes,' which play a key role in DNA repair mechanisms and maintaining genomic stability. Restoring NAD+ levels via NMN may support these crucial repair processes.

Research in animal models suggests that NMN can enhance the activity of DNA-repairing enzymes and help protect against age-related DNA damage.

Muscle Function and Physical Performance

NAD+ is vital for muscle health and function. Declining NAD+ levels with age can contribute to muscle weakness and reduced endurance. NMN supplementation is being explored for its potential to support muscle strength, endurance, and overall physical performance.

Human clinical trials have shown promising results, with NMN supplementation partly improving muscle strength, performance, and walking distance in healthy older men and enhancing aerobic capacity in trained runners.

Metabolic Health (Insulin Sensitivity & Weight Management)

NAD+ plays a role in regulating metabolism, including glucose and fat metabolism. Some research suggests NMN may support healthy insulin sensitivity and potentially aid in managing age-associated weight gain.

Animal studies have indicated NMN's ability to improve insulin sensitivity and suppress age-associated weight gain. A small human study in postmenopausal women with prediabetes showed improved skeletal muscle insulin signaling and insulin sensitivity with NMN.

Cardiovascular Health

Maintaining healthy blood vessels and circulation is crucial for cardiovascular health. NAD+ is involved in processes that support vascular function. NMN's potential to boost NAD+ may contribute to better cardiovascular well-being.

Some animal studies suggest NMN can help reduce arterial stiffness and improve blood vessel function. Human research on this specific benefit is still limited but an area of active investigation.

Neuroprotection and Cognitive Function

NAD+ is important for brain cell health and function. Declining NAD+ levels have been linked to age-related cognitive decline. NMN is being studied for its potential to support brain health, memory, and cognitive clarity.

Preclinical studies in animal models have shown NMN's potential to improve cognitive function and protect brain cells against certain types of damage. Human studies are needed to confirm these effects.

Disclaimer: The information on this website is for educational purposes only and is based on current scientific research and my own personal experience. While much of the foundational research on NMN's benefits has been conducted in animal models, human studies are emerging. It's crucial to understand that more extensive, long-term human trials are still needed to fully substantiate these potential benefits in humans. This is not medical advice, and you should always consult with a healthcare professional before starting any new supplement regimen.